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Relation between birth weight at term and systolic blood pressure in adolescence

University of WAles College of Medicine, Heath Park, Cardiff C4 4XN Correspondence to: Professor Davies.

Abstract

Objective : To examine whether birth weight is related to systolic blood pressure during adolescence.
Design : Retrospective (comparative) cohort study. The observers who traced and studied the subjects were unaware of their case-control status.
Subjects : 330 subjects were born in Cardiff in 1975-7. Cases who were low birth weight at term (<2500 g) were matched with controls of normal birth weight (3000-3800 g) at term.
Main outcome measures : Systolic blood pressure measured by random zero sphygmomanometry in the subject's right arm with the subject supine, corrected for size and age.
Results : The mean age at examination was 15.7 years. The mean systolic blood pressure of the cases was 105.8mm Hg and of the controls 107.5 mm Hg. The corrected difference (95% confidence interval) in systolic blood pressure between the cases and controls was 1 mm Hg (-3 to +1 mm Hg; two tailed probability 0.33).
Conclusion : Systolic blood pressure in adolescents of low birth weight is not significantly different from that of adolescents of normal birth weights.

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Birth weight and blood pressure in adolescence studies may be misleading

D J P Barker, C M Law, J A Davis, J W A Matthes, P A Lewis, D P Davis, and J Bethel
BMJ 1994 308: 1634. [Extract] [Full Text]

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