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Risk of diagnosis of ovarian cancer after raised serum CA 125 concentration: a prospective cohort study

^a Ovarian Cancer Screening Unit, Department of Gynaecological Oncology, St Bartholomew's Hospital and The Royal London Hospital, London EC1A 7BE, ^b Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston 02114-2521, United States

Correspondence to: Mr Jacobs.

Abstract

Objective: To determine the risk of invasive epithelial ovarian cancer and fallopian tube cancer associated with a raised concentration of the tumour marker CA 125 in asymptomatic postmenopausal women.
Design: Serum CA 125 concentration was measured annually in study participants for one to four years. Participants with a concentration >/=30 U/ml were recalled for abdominal ultrasonography. Follow up was by annual postal questionnaire.
Setting: General practice, occupational health departments, ovarian cancer screening unit in a teaching hospital.
Subjects: 22 000 volunteers, all postmenopausal women >/=45 years of age; recruited between 1 June 1986 and 1 May 1990.
Intervention: Surgical investigation if the ultrasound examination was abnormal.
Main outcome measures: Cumulative and relative risk of developing an index cancer (invasive epithelial cancer of the ovary or fallopian tube) after a specified CA 125 result.
Results: 49 index cancers developed in the study population during a mean follow up of 6.76 years. The overall cumulative risk of developing an index cancer was 0.0022 for the entire study population and was lower for women with a serum CA 125 concentration <30 U/ml (cumulative risk 0.0012) but was appreciably increased for women with a concentration >/=30 U/ml (0.030) and >100 U/ml (0.149). Compared with the entire study population the relative risk of developing an index cancer within one year and five years was increased 35.9-fold (95% confidence interval 18.3 to 70.4) and 14.3-fold (8.5 to 24.3) respectively after a serum CA 125 concentration >/=30 U/ml and 204.8-fold (79.0 to 530.7) and 74.5-fold (31.1 to 178.3) respectively after a concentration >/=100 U/ml.
Conclusion: CA 125 is a powerful index of risk of ovarian and fallopian tube cancer in asymptomatic postmenopausal women.

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Recruitment to multicentre trials—lessons from UKCTOCS: descriptive study

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BMJ 2008 337: a2079. [Abstract] [Full Text] [PDF]

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