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Body weight: implications for the prevention of coronary heart disease, stroke, and diabetes mellitus in a cohort study of middle aged men

^a Department of Primary Care and Population Sciences, Royal Free Hospital School of Medicine, London NW3 2PF

Correspondence to: Professor Shaper

Objective:To determine the body mass index associated with the lowest morbidity and mortality.
Design:Prospective study of a male cohort.
Setting:One general practice in each of 24 British towns.
Subjects:7735 men aged 40-59 years at screening.
Main outcome measures:All cause death rate, heart attacks, and stroke (fatal and non-fatal) and development of diabetes, or any of these outcomes (combined end point) over an average follow up of 14.8 years.
Results:There were 1271 deaths from all causes, 974 heart attacks, 290 strokes, and 245 new cases of diabetes mellitus. All cause mortality was increased only in men with a body mass index (kg/m²) <20 and in men with an index 30. However, risk of cardiovascular death, heart attack, and diabetes increased progressively from an index of <20 even after age, smoking, social class, alcohol consumption, and physical activity were adjusted for. For the combined end point the lowest risks were seen for an index of 20.0-23.9. In never smokers and former smokers, deaths from any cause rose progressively from an index of 20.0-21.9 and for the combined end point, from 20.0-23.9. Age adjusted levels of a wide range of cardiovascular risk factors rose or fell progressively from an index <20.
Conclusion:A healthy body mass index in these middle aged British men seems to be about 22.

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