One day treatment is as effective as seven to eradicate H pylori

doi:10.1136/bmj.328.7440.0-f

BMJ 2004;328 (13 March), doi:10.1136/bmj.328.7440.0-f

Filler

POEM^*

One day treatment is as effective as seven to eradicate H pylori

The first 150 words of the full text of this article appear below.

Question Is a one day treatment of Helicobacter pylori as effectiveas a seven day regimen in patients with dyspepsia?

Synopsis The researchers recruited 160 adult patients with dyspepsiascoring 3 or higher (of a possible 20) on the Glasgow dyspepsiaseverity score (GDSS) and with a positive urea breath test (signifyingthe presence of H pylori). Patients were randomised to receiveeither a four drug cocktail for one day or treatment with threedrugs for seven days. Allocation may not have been concealedfrom the enrolling researcher (patients randomised to receivethe seven day treatment were an average seven years older thanthe other patients and less likely to smoke). The one day regimenconsisted of two tablets of 262 mg bismuth subsalicylate (Pepto-Bismol),500 mg metronidazole (Flagyl), and 2 g amoxicillin (suspension),all taken four times over the course of the day, along with60 mg lansoprazole . . . [Full text of this article]