H pylori eradication is cost effective for non-ulcer dyspepsia

The efficacy of Helicobacter pylori eradication as a treatment for non-ulcer dyspepsia remains controversial. On page 659 Moayyedi et al update previous systematic reviews and report a meta-analysis of nine trials evaluating 2541 patients with non-ulcer dyspepsia. H pylori eradication was associated with a small but significant reduction in dyspepsia symptoms. On the basis of these results 15 patients infected with H pylori would need to be treated to cure one extra case of non-ulcer dyspepsia. Despite the modest effect, a Markov model comparing H pylori eradication with antacid treatment shows that eradication, at a cost of £56 per month free of dyspepsia, could be cost effective.

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Relevant Article

Systematic review and economic evaluation of Helicobacter pylori eradication treatment for non-ulcer dyspepsia

Paul Moayyedi, Shelly Soo, Jonathan Deeks, David Forman, James Mason, Michael Innes, and Brendan Delaney
BMJ 2000 321: 659-664. [Abstract] [Full Text] [PDF]