Over-matching can cause bias

Over-matching in case-control studies can be a design fault and may lead to bias, say Marsh and colleagues (p 327). They describe a case-control study of workers at a nuclear reprocessing plant in which over-matching obscured the relation between cumulative radiation dose and mortality from leukaemia.


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Relevant Article

Removal of radiation dose response effects: an example of over-matching
J L Marsh, J L Hutton, and Keith Binks
BMJ 2002 325: 327-330. [Extract] [Full Text] [PDF]

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