BMJ 2003;326 (24 May), doi:10.1136/bmj.326.7399.0
Antibiotic combinations have no advantage in febrile neutropenia
Combinations of 
lactam with an aminoglycoside have no advantage over
treatment with lactam monotherapy for patients with fever and
neutropenia. Paul and colleagues (p
1111) carried out a systematic review and meta-analysis of 47
studies, amounting to 7807 patients. Overall survival was no better with
combination therapy than with monotherapy, and adverse effects were more
common. Furthermore, broad spectrum monotherapy was a more successful
treatment. The authors conclude that broad spectrum monotherapy offers an
overall benefit.
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lactam monotherapy versus lactam-aminoglycoside combination therapy for fever with neutropenia: systematic review and meta-analysis
- Mical Paul, Karla Soares-Weiser, and Leonard Leibovici
BMJ 2003 326: 1111.[Abstract] [Full Text] [PDF]
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