Fifths of nutrient intake 1 2 3 4 5 P for trend Total fat Median intake (g/day) 54 64 70 77 86 — Ischaemic stroke: No of cases 89 87 91 97 91 — Adjusted for age and smoking 1.0 0.96 (0.72 to 1.29) 0.97 (0.72 to 1.30) 1.04 (0.78 to 1.39) 0.93 (0.68 to 1.25) 0.91 Multivariate* 1.0 0.93 (0.68 to 1.26) 1.02 (0.74 to 1.39) 1.02 (0.74 to 1.42) 0.91 (0.65 to 1.28) 0.77 Haemorrhagic stroke: No of cases 18 30 28 23 26 — Adjusted for age and smoking 1.0 1.66 (0.93 to 2.98) 1.50 (0.83 to 2.71) 1.23 (0.66 to 2.30) 1.32 (0.71 to 2.45) 0.73 Multivariate* 1.0 1.76 (0.95 to 3.25) 1.49 (0.79 to 2.83) 1.18 (0.60 to 2.35) 1.16 (0.58 to 2.32) 0.83 Animal fat Median intake (g/day) 25 33 39 45 54 — Ischaemic stroke: No of cases 80 90 95 88 102 — Adjusted for age and smoking 1.0 1.07 (0.78 to 1.45) 1.13 (0.84 to 1.53) 1.05 (0.77 to 1.43) 1.16 (0.86 to 1.58) 0.55 Multivariate* 1.0 1.14 (0.83 to 1.56) 1.12 (0.81 to 1.55) 1.04 (0.74 to 1.46) 1.20 (0.84 to 1.70) 0.47 + vegetable fat 1.0 1.11 (0.81 to 1.53) 1.10 (0.79 to 1.52) 1.02 (0.72 to 1.44) 1.15 (0.80 to 1.65) 0.61 Haemorrhagic stroke: No of cases 21 21 25 35 23 — Adjusted for age and smoking 1.0 0.95 (0.52 to 1.77) 1.14 (0.63 to 2.06) 1.61 (0.92 to 2.82) 1.01 (0.54 to 1.90) 0.45 Multivariate* 1.0 0.95 (0.50 to 1.79) 1.12 (0.60 to 2.10) 1.49 (0.80 to 2.78) 0.90 (0.45 to 1.81) 0.90 + vegetable fat 1.0 0.92 (0.49 to 1.74) 1.08 (0.58 to 2.04) 1.44 (0.77 to 2.70) 0.86 (0.42 to 1.77) 0.99 Vegetable fat Median intake (g/day) 20 26 30 34 42 — Ischaemic stroke: No of cases 94 105 96 70 90 — Adjusted for age and smoking 1.0 1.18 (0.89 to 1.56) 1.11 (0.83 to 1.47) 0.82 (0.60 to 1.12) 0.98 (0.74 to 1.31) 0.27 Multivariate* 1.0 1.22 (0.91 to 1.62) 1.23 (0.91 to 1.66) 0.83 (0.60 to 1.16) 1.07 (0.77 to 1.47) 0.66 + animal fat 1.0 1.22 (0.91 to 1.62) 1.24 (0.92 to 1.67) 0.84 (0.60 to 1.18) 1.09 (0.78 to 1.51) 0.79 Haemorrhagic stroke: No of cases 25 23 27 27 23 — Adjusted for age and smoking 1.0 0.96 (0.54 to 1.69) 1.16 (0.68 to 2.00) 1.17 (0.68 to 2.04) 0.95 (0.53 to 1.69) 0.83 Multivariate* 1.0 1.01 (0.56 to 1.82) 1.20 (0.68 to 2.13) 1.25 (0.70 to 2.25) 0.87 (0.46 to 1.63) 0.80 + animal fat 1.0 1.00 (0.56 to 1.80) 1.20 (0.67 to 2.13) 1.24 (0.68 to 2.24) 0.86 (0.45 to 1.64) 0.80 Saturated fat Median intake (g/day) 17 21 24 26 31 — Ischaemic stroke: No of cases 81 92 95 88 99 — Adjusted for age and smoking 1.0 1.10 (0.82 to 1.49) 1.15 (0.86 to 1.54) 1.01 (0.75 to 1.38) 1.08 (0.80 to 1.46) 0.65 Multivariate* 1.0 1.16 (0.85 to 1.59) 1.19 (0.86 to 1.65) 1.08 (0.77 to 1.52) 1.16 (0.81 to 1.65) 0.59 + poly, mono, trans 1.0 1.24 (0.87 to 1.76) 1.26 (0.84 to 1.88) 1.13 (0.73 to 1.76) 1.21 (0.75 to 1.97) 0.63 Haemorrhagic stroke: No of cases 18 24 34 26 23 — Adjusted for age and smoking 1.0 1.30 (0.71 to 2.39) 1.86 (1.05 to 3.31) 1.36 (0.73 to 2.54) 1.15 (0.60 to 2.19) 0.63 Multivariate* 1.0 1.27 (0.66 to 2.42) 1.74 (0.93 to 3.26) 1.34 (0.68 to 2.66) 0.99 (0.48 to 2.04) 0.85 + poly, mono, trans 1.0 1.30 (0.64 to 2.64) 1.93 (0.91 to 4.08) 1.56 (0.67 to 3.67) 1.17 (0.45 to 3.07) 0.83 Monounsaturated fat Median intake (g/day) 20 24 27 30 34 — Ischaemic stroke: No of cases 90 82 91 99 93 — Adjusted for age and smoking 1.0 0.88 (0.65 to 1.18) 0.99 (0.74 to 1.33) 1.06 (0.80 to 1.41) 0.88 (0.66 to 1.19) 0.96 Multivariate* 1.0 0.89 (0.65 to 1.21) 1.03 (0.75 to 1.42) 1.03 (0.74 to 1.42) 0.91 (0.65 to 1.28) 0.83 + poly, sat, trans 1.0 0.85 (0.59 to 1.22) 1.01 (0.67 to 1.53) 1.06 (0.67 to 1.68) 1.00 (0.58 to 1.70) 0.85 Haemorrhagic stroke: No of cases 22 27 25 23 28 — Adjusted for age and smoking 1.0 1.22 (0.70 to 2.15) 1.14 (0.64 to 2.02) 1.04 (0.57 to 1.87) 1.14 (0.64 to 2.03) 0.82 Multivariate* 1.0 1.23 (0.68 to 2.22) 1.00 (0.54 to 1.88) 0.91 (0.47 to 1.75) 0.95 (0.49 to 1.83) 0.62 + Poly, sat, trans 1.0 0.96 (0.48 to 1.93) 0.69 (0.30 to 1.56) 0.61 (0.24 to 1.55) 0.68 (0.24 to 1.96) 0.40 Polyunsaturated fat Median intake (g/day) 10 11 13 14 17 — Ischaemic stroke: No of cases 96 101 92 89 77 — Adjusted for age and smoking 1.0 1.13 (0.85 to 1.50) 1.04 (0.78 to 1.39) 1.03 (0.77 to 1.38) 0.88 (0.65 to 1.19) 0.28 Multivariate* 1.0 1.14 (0.85 to 1.53) 1.11 (0.82 to 1.49) 0.99 (0.73 to 1.34) 0.88 (0.64 to 1.21) 0.25 + mono, sat, trans 1.0 1.15 (0.85 to 1.55) 1.11 (0.81 to 1.53) 0.98 (0.70 to 1.37) 0.86 (0.59 to 1.25) 0.26 Haemorrhagic stroke: No of cases 27 22 28 25 23 — Adjusted for age and smoking 1.0 0.87 (0.50 to 1.52) 1.14 (0.67 to 1.93) 1.00 (0.58 to 1.73) 0.92 (0.53 to 1.59) 0.97 Multivariate* 1.0 0.85 (0.47 to 1.52) 1.12 (0.64 to 1.96) 1.02 (0.57 to 1.82) 0.86 (0.47 to 1.56) 0.75 + mono, sat, trans 1.0 0.89 (0.49 to 1.64) 1.20 (0.66 to 2.19) 1.09 (0.57 to 2.09) 0.95 (0.46 to 1.98) 0.99 Trans unsaturated fat Median intake (g/day) 1.67 2.34 2.86 3.44 4.42 — Ischaemic stroke: No of cases 91 93 83 97 91 — Adjusted for age and smoking 1.0 1.01 (0.76 to 1.35) 0.90 (0.67 to 1.22) 1.10 (0.83 to 1.45) 0.93 (0.69 to 1.25) 0.79 Multivariate* 1.0 1.01 (0.75 to 1.37) 0.86 (0.62 to 1.19) 0.98 (0.71 to 1.35) 0.87 (0.62 to 1.22) 0.42 + poly, mono, sat 1.0 0.96 (0.70 to 1.33) 0.80 (0.57 to 1.14) 0.90 (0.63 to 1.29) 0.80 (0.54 to 1.17) 0.26 Haemorrhagic stroke: No of cases 18 29 22 22 34 — Adjusted for age and smoking 1.0 1.66 (0.93 to 2.97) 1.20 (0.63 to 2.26) 1.24 (0.66 to 2.31) 1.78 (0.99 to 3.19) 0.16 Multivariate* 1.0 1.54 (0.83 to 2.87) 1.16 (0.59 to 2.27) 1.06 (0.53 to 2.15) 1.76 (0.90 to 3.45) 0.20 + poly, mono, sat 1.0 1.44 (0.76 to 2.73) 1.13 (0.55 to 2.30) 1.11 (0.53 to 2.36) 1.90 (0.90 to 3.98) 0.13 Cholesterol Median intake (mg/d) 189 239 278 321 398 — Ischaemic stroke: No of cases 87 81 85 89 113 — Adjusted for age and smoking 1.0 0.90 (0.67 to 1.23) 0.90 (0.67 to 1.22) 0.89 (0.65 to 1.20) 1.06 (0.79 to 1.41) 0.72 Multivariate* 1.0 0.97 (0.72 to 1.32) 0.85 (0.62 to 1.16) 0.82 (0.60 to 1.13) 1.02 (0.75 to 1.39) 0.99 + poly, mono, sat, trans 1.0 0.93 (0.68 to 1.27) 0.80 (0.57 to 1.10) 0.76 (0.54 to 1.06) 0.93 (0.66 to 1.30) 0.63 Haemorrhagic stroke: No of cases 24 19 25 24 33 — Adjusted for age and smoking 1.0 0.77 (0.42 to 1.38) 0.95 (0.55 to 1.65) 0.82 (0.46 to 1.44) 1.10 (0.66 to 1.86) 0.51 Multivariate* 1.0 0.70 (0.37 to 1.32) 1.02 (0.57 to 1.83) 0.91 (0.50 to 1.65) 1.04 (0.58 to 1.88) 0.61 + poly, mono, sat, trans 1.0 0.66 (0.34 to 1.26) 0.99 (0.54 to 1.82) 0.90 (0.48 to 1.70) 1.16 (0.61 to 2.20) 0.37 Keys score Median score 27.0 33.1 37.0 41.0 47.4 — Ischaemic stroke: No of cases 86 84 88 91 106 — Adjusted for age and smoking 1.0 0.93 (0.69 to 1.25) 0.99 (0.73 to 1.33) 0.97 (0.72 to 1.30) 1.04 (0.77 to 1.39) 0.66 Multivariate* 1.0 0.92 (0.67 to 1.26) 0.96 (0.69 to 1.33) 0.96 (0.69 to 1.34) 1.04 (0.74 to 1.48) 0.71 Haemorrhagic stroke: No of cases 19 21 28 33 24 — Adjusted for age and smoking 1.0 1.04 (0.55 to 1.94) 1.48 (0.83 to 2.65) 1.64 (0.92 to 2.92) 1.00 (0.52 to 1.92) 0.40 Multivariate* 1.0 1.12 (0.58 to 2.15) 1.46 (0.77 to 2.76) 1.59 (0.84 to 3.02) 1.07 (0.53 to 2.19) 0.68

Poly=polyunsaturated fat; mono=monounsaturated fat; sat=saturated fat; trans=trans unsaturated fat.

^* Adjusted for body mass index (<21, 21-22.9, 23-24.9, 25-29.9, or 30), physical activity (fifths), history of hypertension (yes or no), smoking status (never, past, and current with 1-14, 15-24, or 25 cigarettes/day), aspirin use (yes or no), multivitamin use (yes or no), and consumption of alcohol (0, 0.1-9.9, 10-19.9, 20-29.9, or 30g/day), potassium (fifths), fibre (fifths), and vitamin E (fifths), total servings of fruit and vegetables (fifths), total energy intake (continuous), and hypercholesterolaemia (yes or no) at baseline.

Additional adjustments. All additional variables are fifths.

Keys score=1.26(2S-P)+1.5(square root (C)); S=percentages of total energy from saturated fat; P=percentages of total energy from polyunsaturated fat; C=daily cholesterol intake in mg/1000 kcal.