BMJ  2003;327 (11 October), doi:10.1136/bmj.327.7419.0

Compliance therapy does not improve drug adherence in schizophrenia

Pragmatic talking therapy designed to improve adherence to drug treatment in schizophrenia patients fails. O'Donnell and colleagues (p 834) randomised 56 schizophrenia patients either to compliance therapy, a cognitive behavioural based motivational and psychoeducational intervention, or to non specific counselling. They found that adherence at one year was no better among patients in the intervention group, nor did patients' symptoms or quality of life improve. They also found that patients' attitudes to treatment strongly predicted later adherence.

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