Rate ratio | ||||
---|---|---|---|---|
Drug use | No of cases (n=5579) | No of controls (n=13 300) | Crude | Adjusted* (95% CI) |
Lithium | ||||
Any use in the year before index date†: | 20 | 27 | 1.77 | 1.80 (1.00 to 3.24) |
1-4 prescriptions | 2 | 8 | 0.60 | 0.71 (0.15 to 3.45) |
≥5 prescriptions | 18 | 19 | 2.26 | 2.18 (1.14 to 4.19) |
Current use (within 60 days before index date†) | 19 | 22 | 2.06 | 2.08 (1.11 to 3.90) |
Carbamazepine | ||||
Any use in the year before index date†: | 36 | 79 | 1.09 | 1.04 (0.70 to 1.54) |
1-4 prescriptions | 18 | 41 | 1.05 | 1.02 (0.58 to 1.79) |
≥5 prescriptions | 18 | 38 | 1.13 | 1.05 (0.58 to 1.85) |
Current use (within 60 days before index date†) | 18 | 48 | 0.90 | 0.83 (0.48 to 1.44) |
↵* Adjusted for age, sex, residence in the country, previous involvement in an injurious motor vehicle crash, chronic disease score, and exposure in the 60 days before the index date to antidepressants, anti-epileptics, benzodiazepines, antipsychotics, antimigraine drugs, muscle relaxants, or narcotic analgesics.
↵† The date of each driver's first crash in the follow up period (for cases) or a random date (for controls).