Clinical outcomes for patients being managed for depression with evidence based model or usual care. Values are percentages (number of patients/total number) unless stated otherwise

Outcomes Intervention patients Usual care patients Between group difference or odds ratio (95% CI)* P value Mean (SD) severity of depression Baseline 2.04 (0.66) 1.98 (0.65) 0.15 (–0.03 to 0.33) 0.105 3 months 1.16 (0.80) 1.29 (0.76) –0.16 (–0.32 to –0.002) 0.048 6 months 0.97 (0.80) 1.09 (0.74) –0.20 (–0.39 to –0.014) 0.036 Response 3 months 53.0 (97/183) 34.2 (52/152) 2.2 (1.4 to 3.4) 0.001 6 months 59.9 (106/177) 46.6 (68/146) 1.7 (1.1 to 2.7) 0.021 Remission 3 months 26.2 (48/183) 16.5 (25/152) 2.1 (1.2 to 3.7) 0.018 6 months 37.3 (66/177) 26.7 (39/146) 1.9 (1.2 to 3.3) 0.014

^* Adjusted for variability in practices. All patients have at least 0.5 score on Hopkins symptom checklist-20 at baseline.

Scores on Hopkins symptom checklist-20.

At least 50% decrease in depression score from baseline.

Score of <0.5 on Hopkins symptom checklist-20.