BMJ  2005;331 (30 July), doi:10.1136/bmj.331.7511.0-a

Advice on dose adjustment in renal impairment is inconsistent

Recommendations for dose adjustment in patients with renal impairment differ greatly between the British National Formulary, Martindale: the Complete Drug Reference, American Hospital Formulary System Drug Information, and Drug Prescribing in Renal Failure. Comparing the advice that the four sources give for the 100 drugs that are most commonly prescribed in their hospital, Vidal and colleagues (p 263) found that the sources disagreed on the definition of renal impairment and differed in recommendations for specific drugs. For example, the British National Formulary and Martindale disagreed on whether the dosage needed adjusting at all for 11 drugs. Further, none of the sources clearly presented the methods and primary sources they used for their recommendations, and many criteria were described in qualitative terms.

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Systematic comparison of four sources of drug information regarding adjustment of dose for renal function

Liat Vidal, Maya Shavit, Abigail Fraser, Mical Paul, and Leonard Leibovici
BMJ 2005 331: 263. [Abstract] [Full Text] [PDF]