A walk on the wild side—emerging wildlife diseases

They increasingly threaten human and animal health

Emerging infectious diseases have been creeping up the research agenda since at least 1992, when the US Institute of Medicine defined them as infectious diseases that have recently increased in incidence or geographical range, recently been discovered, or are caused by newlyevolved pathogens.1 Diseases that have recently moved into new species can be added to this defining list.2 More recently, the emergence of diseases with high case fatality rates—such as AIDS, severe acute respiratory syndrome (SARS) and H5N1 avian influenza—have catapulted emerging infectious diseases to the top of the medical and political agendas, simultaneously highlighting the importance of wildlife as reservoirs or vectors for disease.

A topical example is avian influenza, which can cause human pandemics after genetic mutation or reassortment between influenza viruses of wild and domestic birds, other animals, and humans. The prospect of a global pandemic of H5N1 is very real, at least for wild birds and mammals, and possibly also for humans. Another example is HIV infection and AIDS, which emerged from at least two non-human primate reservoirs in Africa.3 Fruit bats havebeen implicated as reservoirs of several high profile viral zoonoses that have emerged over the past decade, including SARS.4 For some pathogens, secondary “amplifier” hosts are required for transmission to humans: thus, Hendra virus emerged from fruitbats to horses and then to humans in Australia in 1994-5, and Nipah virus emerged from fruit batsto pigs and dogs to humans in Malaysia in 1998-9.2 Nipah virus has since emerged in Bangladesh, where the virus is genetically distinct from that in South East Asia,5 and human to human transmission possibly occurs.6 Nipah virus should be kept on the “radar screen” for potential human pandemics: in the 1998-9 outbreak 106 people died in the absence of transmission between humans.

Of the 1415 known human pathogens, 61% are zoonotic.7 Ofpathogens causing emerging infectious diseases, however, 75% are zoonotic, with wildlife being anincreasingly important source.2 This is not surprising, as non-zoonoses will likely already be endemic while zoonoses from domesticated species probably emerged over millenniums of close association with humans. Indeed, some established human diseases, such as measles, probably originated from these animals around the time of domestication.8 Wildlife, however, continue to be a reservoir of unfamiliar microorganisms from which previously unknown pathogens continue to emerge. It is estimated that only about a fifth to a 50th of species have been documented,9 sothe reservoir of potential zoonotic pathogens is vast. But why are we now seeing an apparently rapid increase in the emergence of new zoonoses from wildlife?

Pteropus alecto—the black flying fox—known to carry Hendra virus

Credit: STEVEN DAVID MILLER/NATUREPL

One of the major drivers of the emergence of infectious disease is closer human contact with wildlife, primarily caused by human encroachment into, and modification of, wildlife habitat. As the human population continues to grow, our needs for space and resources result in further encroachment into a diminishing natural world. For example, Nipah virus spilled over from fruit bats when forest was cleared for pig farming; Ebola virus outbreaks often are linked to hunting for “bushmeat” or to mining development; and the AIDS pandemic originated from human encroachment into African forests for food.

New zoonoses have probably emerged many times from wildlife historically but failed to spread from the focus of emergence: infected people either died or recovered before contacting larger human populations. In modern times, however, the exponential rise in volume and speed of trade and travel has transformed the epidemiology of emerging infectious diseases, giving the outcomes of emergence events global rather than local importance. The international trade in wildlife is now huge, with hundreds of millions of wild animals and their products being traded globally each year.10 Also, travellers can be in the middle of a tropical jungle one day and commuting to their desk in London the next. The emergence of West Nile virus in North America, and AIDS and SARS globally, for example, arose from such travel and trade. This globalisation of people and products is difficult to control and is largely related to increasing air transportation. With world air travel expected to grow at about 5% a year for at least the next 20 years,11 the problem of emerging infectious diseases will continue to grow.

Emerging infectious diseases are not only a problem for human health but are a major threat to animal welfare and to species conservation.2 12 The same principles for disease emergence in humans apply to wildlife. A study of the drivers of disease emergence in wildlife showed that human movement of pathogens by trade and travel is the most important.12 The emergence and spread of new wildlife diseases increases the potential for disease emergence in humans, as has occurred with the spread of West Nile virus to, and within, the Americas.12 Some emerging infectious diseases also threaten domesticated species, such as the threat West Nile virus poses to the US racehorse industry and the slaughter of 1.1 million pigs to control emergence of Nipah virus in Malaysia. Through emerging infectious diseases, therefore, the medical, veterinary, and wildlife conservation professions share a common agenda. The problem is not small, and tackling it will not be easy, but recognising a common problem is, atleast, a start.