BMJ  2006;332:745 (1 April), doi:10.1136/bmj.332.7544.745-a

News

Scientists find new disease: motivational deficiency disorder

Sydney

Extreme laziness may have a medical basis, say a group of high profile Australian scientists, describing a new condition called motivational deficiency disorder (MoDeD).

The condition is claimed to affect up to one in five Australians and is characterised by overwhelming and debilitating apathy. Neuroscientists at the University of Newcastle in Australia say that in severe cases motivational deficiency disorder can be fatal, because the condition reduces the motivation to breathe.

Neurologist Leth Argos is part of the team that has identified the disorder, which can be diagnosed using a combination of positron emission tomography and low scores on a motivation rating scale, previously validated in elite athletes. "This disorder is poorly understood," Professor Argos told the BMJ. "It is underdiagnosed and undertreated."

Professor Argos is an adviser to a small Australian biotechnology company, Healthtec, which is currently concluding phase II trials of indolebant, a cannabinoid CB1 receptor antagonist. Although still unpublished, the preliminary results from the company's phase II studies are promising, according to Professor Argos: "Indolebant is effective and well tolerated. One young man who could not leave his sofa is now working as an investment adviser in Sydney."

David Henry, a clinical pharmacologist at the University of Newcastle and long time critic of pharmaceutical marketing strategies, says that although he appreciates that some people with severe motivational deficiency disorder may need treatment, he is concerned that the prevalence estimates of one in five are inflated and that ordinary laziness is being medicalised. "Indolebant may bring some relief to those with a debilitating form of MoDeD, but common laziness is not a disease. People have an absolute right to just sit there."

"People have an absolute right to just sit there" Credit: ALEX & IAILA/STONE+/GETTY IMAGES

 

Professor Henry has organised a conference at Newcastle University to highlight what he describes as "disease mongering," which will take place 11-13 April 2006 (www.diseasemongering.org). The conference will produce a consensus statement to be published in PLoS Medicine, which will launch its theme issue on disease mongering this week.

A study of the economic impacts of motivational deficiency disorder estimates the condition may be costing the Australian economy $A2.4bn (£970m; 1.4bn; $1.7bn) a year in lost productivity. This has prompted calls from industry and advocacy groups for a fast tracking of the regulatory assessment of indolebant in Australia and worldwide.

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Watch video on motivational deficiency disorder

This article has been cited by other articles:

• Paccaud, F. (2007). Implausible diseases and public health. Eur J Public Health 17: 410-410 [Full text]  
• Atkins, D. (2006). New disease: motivational deficiency disorder: study ignores economic benefits.. BMJ 332: 916-916 [Full text]  
• Cliff, J. L (2006). New disease: motivational deficiency disorder: too much effort.. BMJ 332: 916-916 [Full text]  

Rapid Responses:

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It always pays to look at the date!

Gerry Waldron
bmj.com, 31 Mar 2006 [Full text]

April fool?

Paddy ONeill
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Epidemic in Gateshead

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April fool?

Tim Marshall
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The chronically unsuccessful

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Too much effort

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Scientists must wait for authentication

Rajan TD
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Ignores economic benefits

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It's true

Graham Luxton
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MoDeD - not new but rediscovered.

Stephen Head
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Gender and Cross cultural analysis needed

Mary E Black
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April 1st.

Vincent P Edwards
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April Fool- Can I be bovvered?

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Apathy rules OK

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