BMJ  2004;329:1067 (6 November), doi:10.1136/bmj.38246.594873.7C (published 14 October 2004)

Paper

The Lambeth Early Onset (LEO) Team: randomised controlled trial of the effectiveness of specialised care for early psychosis

¹ Institute of Psychiatry, De Crespigny Park, London SE5 8AF, ² Lambeth Early Onset Service, South London and Maudsley NHS Trust, London SW9 9NT, ³ Biostatistics Group, School of Epidemiology and Health Science, University of Manchester, Manchester M13 9PT

Abstract

Objective To evaluate the effectiveness of a service for early psychosis.

Design Randomised controlled clinical trial.

Setting Community mental health teams in one London borough.

Participants 144 people aged 16-40 years presenting to mental health services for the first or second time with non-organic, non-affective psychosis.

Interventions Assertive outreach with evidence based biopsychosocial interventions (specialised care group) and standard care (control group) delivered by community mental health teams.

Primary outcome measures Rates of relapse and readmission to hospital.

Results Compared with patients in the standard care group, those in the specialised care group were less likely to relapse (odds ratio 0.46, 95% confidence interval 0.22 to 0.97), were readmitted fewer times ( 0.39, 0.10 to 0.68), and were less likely to drop out of the study (odds ratio 0.35, 0.15 to 0.81). When rates were adjusted for sex, previous psychotic episode, and ethnicity, the difference in relapse was no longer significant (odds ratio 0.55, 0.24 to 1.26); only total number of readmissions ( 0.36, 0.04 to 0.66) and dropout rates ( 0.28, 0.12 to 0.73) remained significant.

Conclusions Limited evidence shows that a team delivering specialised care for patients with early psychosis is superior to standard care for maintaining contact with professionals and for reducing readmissions to hospital. No firm conclusions can, however, be drawn owing to the modest sample size.

Introduction

Worldwide there is interest in developing early intervention services for people with a first psychotic disorder. Fifty such services are to be established in England.^{1 2} The rationale behind these services is that a long duration of untreated psychosis may have a detrimental effect on outcome and that sustained treatment in the two or three years after an acute episode should maintain recovery and rebuild careers, relationships, and leisure pursuits.^3-10 Although the rationale may be compelling, only one randomised controlled trial has studied early intervention in patients with a first episode of psychosis.¹¹ Other evidence comes from studies using historical controls or specific interventions such as atypical antipsychotics, cognitive behavioural therapy, and family therapy.^{4 9 12-21}

We investigated whether a specialist team could achieve better outcomes for people with early non-affective psychotic disorders than existing services. We hypothesised that, over an 18 month period, people receiving specialised care would have more frequent contact with mental health services, fewer relapses, and fewer readmissions to hospital than patients receiving standard care.

Methods

We considered all people aged 16-40 years living in the London borough of Lambeth and presenting to mental health services for the first time with non-affective psychosis (schizophrenia, schizotypal, and delusional disorders, F20-29; international classification of diseases, 10th revision). We also considered people who had presented once but had subsequently disengaged without treatment from routine community services. We excluded those with organic psychosis or a primary alcohol or drug addiction. Non-English speakers were not excluded, but we did exclude asylum seekers who were liable to enforced dispersal.

Lambeth is the seventh most deprived of the 376 local authority boroughs in England and Wales.²² It has a sizeable population from ethnic minority groups and unemployment is around twice the national average (2001 census). Community mental health services are provided through five multiprofessional teams.

Interventions
Assertive outreach for early psychosis
The Lambeth Early Onset (LEO) Team is a community team comprising 10 members of staff (team leader, part time consultant psychiatrist, trainee psychiatrist, half time clinical psychologist, occupational therapist, four community psychiatric nurses, and two healthcare assistants). It was established on the principles of assertive outreach, providing an extended hours service by including weekends and public holidays.² Evidence based interventions adapted to the needs of people with early psychosis included low dose atypical antipsychotic regimens, cognitive behaviour therapy based on manualised protocols,^{17 18} and family counselling and vocational strategies based on established protocols.^{23 24} Adherence to the assertive outreach model and to these treatment protocols was ensured through supervision of cognitive behaviour therapy (PG), medication prescribing, family support, and the assertive outreach model (PP and TKJC). Whereas medication was prescribed to all patients, the range of psychological interventions varied according to need as assessed by the treating clinicans.

Standard care
Patients in the control group received standard care delivered by the community mental health teams. These teams received no additional training in the management of early psychosis, although they were encouraged to follow available guidelines.^{23 25}

Assignment
All referrals to the psychiatric services in Lambeth were screened for possible psychotic symptoms (SC, MF-A, and NR).²⁶ Those passing this initial screen were interviewed by one researcher (NR) to confirm symptoms (using the schedules of clinical assessment in neuropsychiatry) and to establish the likely date of onset and previous contact with services. Finally each patient was assigned a provisional diagnosis.²⁷ Basic demographic and personal data were recorded at this point.

Eligible patients were randomised to specialised care or standard care by permuted random blocks of between two and six. Group allocation was concealed in sealed envelopes. The trial statistician (GD) independently carried out the randomisation and concealment of results. Patients were informed of the randomisation process, and written consent was sought to collect outcome data from case notes and by interview (SC and MF-A) as soon as feasible after randomisation and at follow up 18 months later.

Primary outcomes
Our primary outcome measures were rates of relapse and readmission to hospital. Two of the researchers (TKJC and PG) agreed on the ratings for recovery (full or partial) and relapse, basing these ratings on operationalised criteria (available from authors) applied to extracts of the clinical case notes from which information pertaining to group allocation had been removed. Group allocation remained concealed until completion of the ratings. To test the success of blinding, assessors guessed the group allocation of each patient. The two raters correctly guessed the allocation of 60% (95% confidence interval 52% to 63%) of the patients ( 0.20). Data on readmissions were gathered through the hospital administration system.

Statistical analysis
We determined that we required 120 patients. This was based on an estimate that 60% of patients in the control group and 40% of patients in the specialised care group would relapse at 18 months, at a power of 80% and an of 0.05. We also estimated that 25% of patients would drop out over the 18 months of follow up.

We analysed data using STATA release 7. Using intention to treat analyses we compared the outcomes in both groups at 18 months and determined whether patients had relapsed at any point. Patients who had previously relapsed but had recovered by 18 months were included as "well" at that point. Differences are reported as odds ratios and based on the ² statistic. Readmissions were similarly analysed. Further analyses compared the two groups for total number of readmissions across the follow up period, total duration of hospital stay, and the proportion of admissions that occurred under the mental health act. Subsequent analyses controlled for possible imbalances in characteristics at baseline. We used an analysis of covariance with logistic regression approaches for categorical data and regression for total number of admissions, readmissions, and duration of hospital stay. Standard errors and confidence intervals were obtained through bootstrap methods.

We estimated the duration of untreated psychosis, defined as the period from the first onset of positive symptoms to initial contact with psychiatric services in patients for whom this was their first contact.

Results

Overall, 319 people presented to psychiatric services between January 2000 and October 2001 with symptoms suggestive of a psychotic disorder. Of these, 144 met the inclusion criteria and were randomised to receive either specialised care or standard care (figure). Data on number of relapses and readmissions to hospital were obtained for 136 (94%) patients over the 18 months of follow up. We had complete information on clinical status (recovered, unwell or relapsed) for 131 (91%) patients at 18 months.

View larger version (52K): [in this window] [in a new window]   Flow of patients through trial

 

Both groups were similar for most characteristics at baseline, although the specialised care group had fewer men, a higher proportion of first psychotic episodes, and a higher proportion of white people (table 1). Patients in the specialised care group also had a longer duration of untreated psychosis, although the difference between the groups was not statistically significant (mean (SD) duration (months) of untreated psychosis: 10.5 (17.2) for specialised care v 7.6 (10.7) for controls).

View this table: [in this window] [in a new window]   Table 1 Baseline characteristics of groups receiving specialised care or standard care for psychosis. Values are numbers (percentages) unless stated otherwise

 

For most patients, admission to hospital was their first experience of mental health care (43 of 71 patients (61%) in specialised care group, 44 of 73 patients (60%) in control group) two thirds of which were involuntary admissions (specialised care 67%, controls 72%).

At 18 months, one patient in the control group had died (unknown cause); 53 (86%) patients in the specialised care group and 44 (68%) patients in the control group were in regular contact with the clinical team (lost to care: odds ratio 0.35, 95% confidence interval 0.15 to 0.81). Patients in the specialised care group were offered more appointments during follow up than controls (mean (SD) number of appointments: 17.4 (9.1) for specialised care v 13.2 (8.7) for controls) and failed to attend a smaller proportion of the appointments (mean (SD) proportion of appointments missed: 0.12 (0.2) for specialised care v 0.33 (0.3) for controls). Seven patients in the specialised care group and 10 control patients were in hospital at the 18 months' follow up. One control patient was in prison.

Patients in the specialised care group were more likely than those in the control group to have been offered psychosocial interventions (table 2).

View this table: [in this window] [in a new window]   Table 2 Contact with mental health services and uptake of treatment over 18 months for patients receiving care for early psychosis. Values are numbers (percentages) of patients unless stated otherwise

 

Patients in the specialised care group were significantly more likely to be in recovery at follow up than patients in the control group; this included patients who had relapsed (table 3). When only those patients who had not relapsed after initial recovery were classified as "well" (specialised care 64%, controls 48%), the difference between groups was attenuated and fell below statistical significance (odds ratio 0.52, 95% confidence interval 0.26 to 1.03).

View this table: [in this window] [in a new window]   Table 3 Primary outcome measures for patients receiving specialised care or standard care for early psychosis. Values are numbers (percentages) of patients unless stated otherwise

 

Most patients in both groups recovered from the index episode (specialised care: full recovery 71%, partial recovery 19%; controls: full recovery 63%, partial recovery 28%). The average time to recovery was 5.5 (SD 4.0) months in both groups. Although there were no differences in these rates, patients in the specialised care group were less likely to relapse than those in the control group (specialised care 30% v controls 48%; P = 0.042). Patients in the specialised care group were also readmitted fewer times during follow up (see table 3).

Although the higher contact with services among patients in the specialised care group remained significant (lost to care: odds ratio 0.28; 95% confidence interval 0.12 to 0.73) when we adjusted for baseline differences in sex, previous psychotic episodes, and ethnic minority group, only the difference in total number of readmissions during follow up remained statistically significant (see table 3).

Discussion

Patients with early psychosis who are cared for by a specialist team are more likely to maintain contact with psychiatric services and to have fewer readmissions to hospital than patients who receive standard care. This finding is, however, limited because our study was underpowered.

The strengths of our study are the use of randomisation, the low attrition for primary outcome data, and the inclusion of all patients with a first episode of non-affective psychosis presenting to secondary mental health services within a defined inner city area.

Our study does, however, have several limitations. We relied on record systems for data on relapse, which are susceptible to errors and biases. Our study is among the first, however, to use an a priori operational definition of recovery and relapse with clear definitions and a rating manual. Attempting to prospectively monitor symptom change by repeated interview is not only costly but also susceptible to differential rates of attrition, with a higher proportion of patients in the intervention group likely to remain in contact and willing to cooperate with interviews. That there were fewer readmissions to hospital in patients receiving specialised care is encouraging, as this outcome is closely linked with relapse and outside the control of the research team.

What is already known on this topic Outcomes for certain psychoses may be improved by early detection and maintenance of treatment for two or three years after onset This ideal is seldom achieved by general psychiatric services What this study adds Patients receiving specialised care for early psychosis maintained better contact with services and had fewer readmissions to hospital than patients receiving standard care The data are limited, however, owing to the small sample size

Despite our efforts to include all first presentations and to minimise the number of people who dropped out, our study was underpowered. If we had attempted to address the issue of multiple primary outcomes (for example, by Bonferroni correction) the findings would not be statistically significant. Also, probably reflecting the modest sample size, the randomisation process did not produce well matched groups, with the specialised care group at baseline having more features of better prognosis for sex, previous psychotic episodes, and ethnicity than the standard care group. This is reflected in the adjusted analysis where only one of the six primary outcomes retained statistical significance.

It might be argued that our results are attributable not so much to the particular benefits of specialist provision of early intervention but to the comparison of such a service with inadequately resourced routine services.²⁸ To some extent this is true, as an earlier study reported that disengagement from routine community services was common.²⁹ It has, however, been an empirical question as to whether establishing a new service would be acceptable to patients and lead to improved outcomes. Finally, it might also be said that our study has been overtaken by the UK's Department of Health initiative to establish 50 new early intervention services, but in practice there are wide variations in implementation with little guidance for service developers on whether they should put the modest increase in funding towards early detection, home treatment, or, as in our case, efforts to prevent relapse.

---

Ethical approval is described more fully on bmj.com

We thank the clinical teams for access to participants and the patients and their carers.

Contributors: TKJC was responsible for the study conception and design, interpretation of the data, and writing the paper. He is the guarantor. PAG was responsible for the study conception and design and interpretation of the data. PP was the clinical lead of the specialised service and ensured that best practice guidelines were followed to early psychosis model. NR carried out the screening and clinical intake assessments and contributed to the study design, execution, and interpretation. SC contributed to the study execution, analysis, and interpretation. MF-A contributed to the execution of the study and analysis and interpretation of the data. GD was responsible for designing and overseeing the randomisation process, carried out the main statistical analysis, and contributed to the interpretation of the data and writing the paper.

Funding: Directorate of Health and Social Care London research and development organisation and management programme (grant No Brixton Early Psychosis Project RDC 01657). The views expressed are those of the authors and not necessarily those of the NHS or the Department of Health.

Competing interests: TKJC and PP have received support for attending seminars and fees for speaking at conferences on early psychosis from Eli Lilly, AstraZeneca, Janssen-Cilag, and Novartis.

Ethical approval: This study was approved by the local research ethics committee.

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(Accepted 4 August 2004)

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