Abstract
We report substantial reductions in the frequency of severe paracetamol hepatotoxicity locally and nationally after legislative limitations on its sale. These reductions were not explained by changes in referral patterns or use of N-acetylcysteine.
MeSH terms
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Acetaminophen / poisoning*
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Acetylcysteine / administration & dosage
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Adult
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Analgesics, Non-Narcotic / poisoning*
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Chemical and Drug Induced Liver Injury*
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Female
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Free Radical Scavengers / administration & dosage
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Humans
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Incidence
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Legislation, Drug*
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Liver Diseases / therapy
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Male
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Poisoning / classification
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Poisoning / epidemiology
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Poisoning / prevention & control
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Severity of Illness Index
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United Kingdom / epidemiology
Substances
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Analgesics, Non-Narcotic
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Free Radical Scavengers
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Acetaminophen
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Acetylcysteine