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Selective chromosome analysis in couples with two or more miscarriages: case-control study

BMJ 2005; 331 doi: https://doi.org/10.1136/bmj.38498.669595.8F (Published 14 July 2005) Cite this as: BMJ 2005;331:137

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An Alternative Therapy

As a student in genetics, I would like to thank the authors of this
paper for this analysis: that the correlation of maternal age, family
history as well as having suffered two or more miscarriages being an
indication for a couple to be carriers of chromosomal abnormalities.

Was transvaginal sonography the method by which all of the females
were clinically diagnosed for complete miscarriages?

Pre-implantation genetic testing is an alternative therapy that can
be used for couples that have had two or more miscarriages. This way the
0.5% to 10.2% chance of having a chromosome abnormality could be lowered
including the risk of having a child with Tuner syndrome, Down syndrome,
trisomy 18 and 13. However, would instigating pre-implantation genetic
testing for all couples who have had two or more miscarriages going to
help drive down the cost of medical care?

Competing interests:
None declared

Competing interests: No competing interests

21 July 2005
Jonathon Weber
Undergraduate Student (Genetics)
53705
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